Research

The International Registry of Acute Aortic Dissection is actively involved in furthering the understanding and treatment for aortic dissections. The following is a list of abstracts and manuscripts published by IRAD. While we are unable to send you these articles, your local library or university may be able to help you obtain any articles of interest.

Manuscripts Submitted or In Press

Hagan PG, Nienaber CA, Isselbacher EM, Bruckman D, Karavite DJ, Russman PL, Evangelista A, Fattori R, Suzuki T, Oh JK, Moore AG, Malouf JF, Pape LA, Gaca C, Sechtem U, Lenferink S, Deutsch HJ, Diedrichs H, Robles JM, Llovet A, Gilon D, Das SK, Armstrong WF, Deeb GM, Eagle KA. The International Registry of Aortic Dissection (IRAD): New insights into an old disease. JAMA 2000; 283(7):897-903.

Mehta RH, Suzuki T, Hagan PG, Bossone E, Gilon D, Llovet A, Maroto LC, Cooper JV, Smith DE, Armstrong WF, Nienaber CA, Eagle KA. Predicting death in patients with acute type A aortic dissection. Circulation 2002; 105(2):200-206.

Januzzi JL, Sabatine MS, Eagle KA, Evangelista A, Bruckman D, Fattori R, Oh JK, Moore AG, Sechtem U, Llovet A, Gilon D, Pape L, O’Gara PT, Mehta R, Cooper JV, Hagan PG, Armstrong WF, Deeb GM, Suzuki T, Nienaber CA, Isselbacher EM. Iatrogenic aortic dissection. Am J of Cardiology 2002; 89(5):623-626.

Moore AG, Eagle KA, Bruckman D, Moon BS, Malouf JF, Fattori R, Evangelista A, Isselbacher EM, Suzuki T, Nienaber CA, Gilon D, Oh JK. Choice of computed tomography, transesophageal echocardiography, magnetic resonance imaging, and aortography in acute aortic dissection: International Registry of Acute Aortic Dissection (IRAD). Am J of Cardiology 2002; 89:1235-1238.

Bossone E, Rampoldi V, Nienaber CA, Trimarchi S, Ballotta A, Cooper JV, Smith DE, Eagle KA, Mehta RH. Usefulness of pulse deficit to predict in-hospital complications and mortality in patients with acute type A aortic dissection. Am J of Cardiology 2002; 89:851-855.

Nallamothu BK, Mehta RH, Saint S, Llovet A, Bossone E, Cooper JV, Sechtem U, Isselbacher EM, Nienaber CA, Eagle KA, Evangelista A. Syncope in acute aortic dissection: diagnostic, prognostic, and clinical implications. Am J of Medicine 2002; 113:468-471.

Mehta RH, O’Gara PT, Bossone E, Nienaber CA, Myrmel T, Cooper JV, Smith DE, Armstrong WF, Isselbacher EM, Pape LA, Eagle KA, Gilon D. Acute type A aortic dissection in the elderly: clinical characteristics, management and outcomes in the current era. J Am Coll Cardiol 2002; 40:685-692.

Mehta RH, Manfredini R, Hassan F, Sechtem U, Bossone E, Oh JK, Cooper JV, Smith DE, Portaluppi F, Penn M, Hutchison S, Nienaber CA, Isselbacher EM, Eagle KA. Chronobiological patterns of acute aortic dissection. Circulation 2002; 106:1110-1115.

Eagle KA, Isselbacher EM, DeSanctis RW. Cocaine-related aortic dissection in perspective. Circulation 2002; 105:1529-1530.

Nienaber CA, Eagle KA. Aortic dissection: new frontiers in diagnosis and management. Part I: from etiology to diagnostic strategies. Circulation 2003; 108:628-635.

Nienaber CA, Eagle KA. Aortic dissection: new frontiers in diagnosis and management. Part II: therapeutic management and follow-up. Circulation 2003; 108:772-778.

Suzuki T, Mehta RH, Ince H, Nagai R, Sakomura Y, Weber F, Sumiyoshi T, Bossone E, Trimarchi S, Cooper JV, Smith DE, Isselbacher EM, Eagle KA, Nienaber CA. Clinical profiles and outcomes of acute type B aortic dissection– lessons from the International Registry of Aortic Dissection (IRAD). Circulation 2003; 108[suppl II]:312-317.

Januzzi JL, Isselbacher EM, Fattori R, Cooper JV, Smith DE, Fang J, Eagle KA, Mehta RH, Nienaber CA, Pape LA. Characterizing the young patient with aortic dissection: results from the International Registry of Aortic Dissection (IRAD). J Am Coll Cardiol 2004; 43:665-669.

Mehta RH, Bossone E, Evangelista A, O’Gara PT, Smith DE, Cooper JV, Oh JK, Januzzi JL, Hutchison S, Gilon D, Pape LA, Nienaber CA, Isselbacher EM, Eagle KA. Acute type B aortic dissection in elderly patients: clinical features, outcomes and simple risk stratification rule. Ann Thorac Surg 2004; 77:1622-29.

Nienaber CA, Fattori R, Mehta RH, Richartz BM, Evangelista A, Petzch M, Cooper JV, Januzzi JL, Ince H, Sechtem U, Bossone E, Fang J, Smith DE, Isselbacher EM, Pape LA, Eagle KA . Gender-related differences in acute aortic dissection. Circulation 2004; 109:3014-3019.

Januzzi JL, Al-Marayati F, Mehta RH, Cooper JV, O'Gara PT, Sechtem U, Bossone E, Evangelista A, Oh JK, Nienaber CA, Eagle KA,  Isselbacher EM. Comparison of aortic dissection in patients with and without marfan’s syndrome (results from the International Registry of Aortic Dissection). Am J of Cardiol 2004; 94:400-402.

Park SW, Hutchison S, Mehta, RH, Isselbacher EM, Cooper JV, Fang J, Evangelista A, Llovet A, Nienaber CA, Suzuki T, Pape LA, Eagle KA, Oh JK. Association of painless acute aortic dissection with increased mortality. Mayo Clin Proc 2004; 79:1252-1257.

Collins JS, Evangelista A, Nienaber CA, Bossone E, Fang J, Cooper JV, Smith DE, O'Gara PT, Myrmel T, Gilon D, Isselbacher EM, Penn M, Pape LA, Eagle KA, Mehta RH. Differences in clinical presentation, management and outcomes of acute type A aortic dissection in patients with and without prior cardiac surgery. Circulation 2004; 110[suppl II]:237-242.

Beckman JA, Mehta RH, Isselbacher EM, Bossone E, Cooper JV, Smith DE, Fang J, Sechtem U, Pape LA, Myrmel T, Nienaber CA, Eagle KA, O’Gara PT. Mortality and branch vessel complications are increased in aortic dissection patients with renal insufficiency. Vasc Med 2004; 9(4):267-270.

Trimarchi S, Nienaber CA, Rampoldi V, Myrmel T, Suzuki T, Mehta RH, Bossone E, Cooper JV, Smith DE, Menicanti L, Frigiola A, Oh JK, Deeb GM, Isselbacher EM, Eagle KA. Contemporary results of surgery in acute type A aortic dissection: the International Registry of Acute Aortic Dissection experience. J Thorac Cardiovasc Surg 2005; 129:112-122.

Tsai TT, Bossone E, Isselbacher EM, Nienaber CA, Evangelista A, Fang J, Smith DE, Cooper JV, Hutchison S, O’Gara P, Eagle KA, Mehta RH. Clinical characteristics of hypotension in patients with acute aortic dissection. Am J Cardiol 2005; 95:48-52.

Evangelista A, Mukherjee D, Mehta RH, O’Gara PT, Fattori R, Cooper JV, Smith DE, Oh JK, Hutchison S, Sechtem U, Isselbacher EM, Nienaber CA, Pape LA, Eagle KA. Acute intramural hematoma of the aorta: a mystery in evolution. Circulation 2005; 111:1063-1070.

Upchurch GR, Nienaber CA, Fattori R, Evangelista A, Oh JK, MD, Cooper JV, Isselbacher EM, Suzuki T, Eagle KA. Acute aortic dissection presenting with primarily abdominal pain: a rare manifestation of a deadly disease. Ann Vasc Surg 2005; 19:367-373.

Mehta RH, Manfredini R, Bossone E, Hutchison S, Evangelista A, Boari B, Cooper JV, Smith DE, O’Gara PT, Gilon D, Pape LA, Nienaber CA, Isselbacher EM, Eagle KA. Does circadian and seasonal variation in occurrence of acute aortic dissection influence in-hospital outcomes? Chronobiology International 2005; 22:343-351.

Januzzi JL, Eagle KA, Cooper JV, Fang J, Sechtem U, Myrmel T, Evangelista A, Oh JK, Llovet A, O’Gara PT, Nienaber CA, Isselbacher EM. Acute aortic dissection presenting with congestive heart failure: results from the International Registry of Acute Aortic Dissection. J Am Coll Cardiol 2005; 46:733-735.

Mukherjee D, Evangelista A, Nienaber CA, Sechtem U, Suzuki T, Trimarchi S, Llovet A, Myrmel T, O’Gara PT, Fang J, Cooper JV, Oh JK, Januzzi, JL, Hutchison S, Fattori R, Pape LA, Isselbacher EM, Eagle KA. Implications of periaortic hematoma in patients with acute aortic dissection: (from the International Registry of Acute Aortic Dissection). Am J Cardiol 2005; 96:1734-1738.

Tsai TT, Nienaber CA, Eagle KA. Contemporary reviews in cardiovascular medicine: acute aortic syndromes. Circulation 2005; 112:3802-3813.

Trimarchi S, Nienaber CA, Rampoldi V, Myrmel T, Suzuki T, Bossone E, Tolva V, Deeb MG, Upchurch GR, Cooper JV, Fang J, Isselbacher EM, Sundt T, Eagle KA. Role and results of surgery in acute type B aortic dissection: insights from the International Registry of Acute Aortic Dissection (IRAD). Circulation 2006; 114:357-364.

Henke PK, Williams DM, Upchurch GR, Proctor M, Cooper JV, Fang J, Nienaber CA, Isselbacher EM, Fattori R, Dasika N, Gemmete J, Stanley JC, Wakefield TW, Eagle KA. Acute limb ischemia associated with type B aortic dissection: clinical relevance and therapy. Surgery 2006; 140:532-539.

Tsai TT, Evangelista A, Nienaber CA, Trimarchi S, Sechtem U, Fattori R, Myrmel T, Pape L, Cooper JV, Smith DE, Fang J, Isselbacher E, Eagle KA. Long-term survival in patients presenting with type A acute aortic dissection: insights from the International Registry of Acute Aortic Dissection (IRAD). Circulation 2006; 114[suppl I]:350-356.

Tsai TT, Fattori R, Trimarchi S, Isselbacher E, Myrmel T, Evangelista A, Hutchison S, Sechtem U, Cooper JV, Smith DE, Pape L, Froehlich J, Raghupathy A, Januzzi JL, Eagle KA, Nienaber CA. Long-term survival in patients presenting with type B acute aortic dissection: insights from the International Registry of Acute Aortic Dissection (IRAD). Circulation 2006; 114:2226-2231.

Rampoldi V, Trimarchi S, Eagle KA, Nienaber CA, Oh JK, Bossone E, Myrmel T, Sangiorgi GM, De Vincentiis C, Cooper JV, Fang J, Smith D, Tsai T, Raghupathy A, Fattori R, Sechtem U, Sundt TM, Isselbacher EM. Simple risk models to predict surgical mortality in acute aortic dissection: the International Registry of Acute Aortic Dissection score. Ann Thorac Surg 2007; 83:55-61.

Tsai TT, Isselbacher EM, Trimarchi S, Bossone E, Pape L, Januzzi JL, Evangelista A, Oh JK, Llovet A, Beckman J, Cooper JV, Smith DE, Froehlich JB, Fattori R, Eagle KA, Nienaber CA. Acute type B aortic dissection: does aortic arch involvement affect management and outcomes? Insights from the International Registry of Acute Aortic Dissection (IRAD). Circulation 2007; 116[suppl I]:150-156.

Bossone E, Evangelista A, Isselbacher E, Trimarchi S, Hutchison S, Gilon D, Llovet A, O’Gara P, Cooper JV, Fang J, Januzzi JL, Mehta RH, Distante A, Nienaber CA, Eagle KA, Armstrong WF. Prognostic role of transesophageal echocardiography in acute type A aortic dissection. Am Heart J 2007; 153:1013-1020.

Tsai TT, Evangelista A, Nienaber CA, Myrmel T, Meinhardt G, Cooper JV, Smith DE, Suzuki T, Fattori R, Llovet A, Froehlich J, Hutchison S, Distante A, Sundt T, Beckman J, Januzzi J, Isselbacher EM, Eagle KA. Partial thrombosis of the false lumen in patients with acute type B aortic dissection. N Engl J Med 2007; 357:349-359.

Pape LA, Tsai TT, Isselbacher EM, Oh JK, O’Gara PT, Evangelista A, Fattori R, Meinhardt G, Trimarchi S, Bossone E, Suzuki T, Cooper JV, Froehlich JB, Nienaber CA, Eagle KA. Aortic diameter ≥5.5 cm is not a good predictor of type A aortic dissection: observations from the International Registry of Acute Aortic Dissection (IRAD). Circulation 2007; 116:1120-1127.

Trimarchi S, Tsai T, Eagle KA, Isselbacher EM, Froehlich J, Cooper JV, Rampoldi V, Upchurch G. Acute abdominal aortic dissection: insights from the International Registry of Acute Aortic Dissection (IRAD). J Vasc Surg 2007; 46:913-919.

Fattori R, Tsai TT, Myrmel T, Evangelista A, Cooper JV, Trimarchi S, Li J, Lovato L, Kische S, Eagle KA, Isselbacher EM, Nienaber CA. Complicated acute type B dissection: is surgery still the best option? A report from the International Registry of Acute Aortic Dissection. J Am Coll Cardiol Intv 2008; 1:395-402.

Raghupathy A, Nienaber CA, Harris KM, Myrmel T, Fattori R, Sechtem U, Oh JK, Trimarchi S, Cooper JV, Booher A, Eagle KA, Isselbacher EM, Bossone E. Geographic differences in clinical presentation, treatment and outcomes in type A acute aortic dissection (from the International Registry of Acute Aortic Dissection). Am J Cardiol 2008; 102:1562-1566.

Suzuki T, Distante A, Zizza A, Trimarchi S, Villani M, Uriarte JAS, Schinosa LLT, Renzulli A, Sabino F, Nowak R, Birkhahn R, Hollander JE, Counselman F, Bossone E, Eagle KA. Preliminary experience with the smooth muscle Troponin-like protein, Calponin, as a novel biomarker for diagnosing acute aortic dissection. Eur Heart J 2008; 29:1439-1445.

Juang D, Braverman AC, Eagle KA. Cardiology patient pages: aortic dissection. Circulation 2008;118:e507-510.

Tsai TT, Trimarchi S, Nienaber CA. Acute aortic dissection: perspectives from the International Registry of Acute Aortic Dissection (IRAD). Eur J V Endovasc Surg 2009; 37:149-159.

Gilon D, Mehta RH, Oh JK, Januzzi JL, Bossone E, Cooper JV, Smith DE, Fang J, Nienaber CA, Eagle KA, Isselbacher EM. Characteristics and in-hospital outcomes of patients with cardiac tamponade complicating type A acute aortic dissection. Am J Cardiol 2009; 103:1029-1031.

Suzuki T, Distante A, Zizza A, Trimarchi S, Villani M, Salerno Uriarte JA, De Luca Tupputi Schinosa L, Renzulli A, Sabino F, Nowak R, Birkhahn R, Hollander JE, Counselman F, Vijayendran R, Bossone E, Eagle KA, IRAD-Bio Investigators. Diagnosis of acute aortic dissection by D-dimer: the International Registry of Acute Aortic Dissection substudy on Biomarkers (IRAD-Bio) experience. Circulation 2009; 119:2702-2707.

Ramanath VS, Oh JK, Sundt TM III, Eagle KA. Acute aortic syndromes and thoracic aortic aneurysm. Mayo Clin. Proc. 2009; 84(5):465-481.

Trimarchi S, Eagle KA, Nienaber CA, Rampoldi V, Jonker FH, De Vincentiis C, Frigiola A, Menicanti L, Tsai T, Froehlich J, Evangelista A, Montgomery D, Bossone E, Cooper JV, Li J, Deeb MG, Meinhardt G, Sundt TM, Isselbacher EM, International Registry of Acute Aortic Dissection Investigators. Role of age in acute type A aortic dissection outcomes: report from the International Registry of Acute aortic Dissection (IRAD). J Thorac Cardiovasc Surg 2010; 140:784-789.

Trimarchi S, Eagle KA, Nienaber CA, Pyeritz RE, Jonker FH, Suzuki T, O'Gara PT, Hutchison SJ, Rampoldi V, Grassi V, Bossone E, Muhs BE, Evangelista A, Tsai TT, Froehlich JB, Cooper JV, Montgomery D, Meinhardt G, Myrmel T, Upchurch GR, Sundt TM, Isselbacher EM, on behalf of the International Registry of Acute Aortic Dissection (IRAD) Investigators. Importance of refractory pain and hypertension in acute type B aortic dissection: insights from the International Registry of Acute Aortic Dissection (IRAD). Circulation 2010; 122:1283-1289.

Booher AM, Isselbacher EM, Nienaber CA, Froehlich JB, Trimarchi S, Cooper JV, Demertzis S, Ramanath VS, Januzzi JL, Harris KM, O'Gara PT, Sundt TM III, Pyeritz RE, Eagle KA; International Registry of Acute Aortic Dissection (IRAD) Investigators. Ascending thoracic aorta dimension and outcomes in acute type B dissection (from the International Registry of Acute Aortic Dissection [IRAD]). Am J Cardiol 2011; 107(2)315-320.

Ramanath VS, Eagle KA, Nienaber CA, Isselbacher EM, Froehlich JB, Montgomery DG, Cooper JV, Gu X, Evangelista A, Voehringer M, Beckman J, Myrmel T, pape L, Pyeritz RE, Hirsch AT, Gilon D, Bossone E. The role of preoperative coronary angiography in the setting of type A acute aortic dissection: insights from the International Registry of Acute Aortic Dissection. Am Heart J 2011; 161(4)790-796.e1.

Rogers AM, Hermann LK, Booher AM, Nienaber CA, Williams DM, Kazerooni EA, Froehlich JB, O'Gara PT, Montgomery DG, Cooper JV, Harris KM, Hutchison S, Evangelista A, Isselbacher EM, Eagle KA. Sensitivity of the Aortic Dissection Detection (AAD) risk score, a novel guideline-based too for identification of acute aortic dissection at initial presentation. Circulation 2011; 123(20):2213-2218.

Trimarchi S, Jonker FH, Hutchison S, Isselbacher EM, Pape LA, Patel HJ, Froehlich JB, Muhs BE, Rampoldi V, Grassi V, Evangelista A, Meinhardt G, Beckman J, Myrmel T, Pyeritz RE, Hirsch AT, Sundt TM III, Nienaber CA, Eagle KA. Descending aortic diameter of 5.5 cm of greater is not an accurate predictor of acute type B aortic dissection. J Thorac Cardiovasc Surg 2011;142(3):e101-107.

Harris KM, Strauss CE, Eagle KA, Hirsch AT, Isselbacher EM, Tsai TT, Shiran H, Fattori R, Evangelista A, Cooper JV, Montgomery DG, Froehlich JB, Nienaber CA. Correlates of delayed recognition and treatment of acute type A aortic dissection: the International Registry of Acute Aortic Dissection (IRAD). Circulation 2011; 124:1911-1918.

Suzuki T, Isselbacher EM, Nienaber CA, Pyeritz RE, Eagle KA, Tsai TT, Cooper JV, Januzzi JL Jr., Braverman AC, Montgomery DG, Fattori R, Pape L, Harris KM, Booher A, Oh JK, Peterson M, Ramanath VS, Froehlich JB. Type-selective benefits of medications in treatment of acute aortic dissection (from the International Registry of Acute Aortic Dissection [IRAD]). Am J Cardiol 2012; 109(1):122-127.

Trimarchi S, Tolenaar JL, Tsai TT, Froehlich JB, Pegorer M, Upchurch GR Jr, Fattori R, Sundt TM III, Isselbacher EM, Nienaber CA, Rampoldi V, Eagle KA. Influence of clinical presentation on the outcomes of acute B aortic dissection: evidences from IRAD. J Cardiovasc Surg 2012; 53:161-168.

Harris KM, Braverman AC, Eagle KA, Woznicki EM, Pyeritz RE, Myrmel T, Peterson MD, Voehringer M, Fattori R, Januzzi JL, Gilon D, Montgomery DG, Nienaber CA, Trimarchi S, Isselbacher EM, Evangelista A. Circulation 2012; 126:S91-S96.

Trimarchi S, Jonker FHW, Froehlich JB, Upchurch GR, Moll FL, Muhs BE, Rampoldi V, Patel JH, Eagle KA. Acute type B aortic dissection in the absence of aortic dilatation. J Vasc Surg 2012; In Press.

Di Eusanio M, Trimarchi S, Patel HJ, Hutchison S, Suzuki T, Peterson MD, Di Bartolomeo R, Folesani G, Pyeritz RE, Braverman AC, Montgomery DG, Isselbacher EM, Nienaber CA, Eagle KA, Fattori R. Clinical presentation, management, and short-term outcomes of patients with type A acute dissection complicated by mesenteric malperfusion: observations from the International Registry of Acute Aortic Dissection. J Thorac Cardiovasc Surg 2012; In Press.

Jonker FHW, Trimarchi S, Rampoldi V, Patel HJ, O'Gara P, Peterson MD, Fattori R, Moll RL, Voehringer M, Pyeritz RE, Hutchison S, Montgomery D, Isselbacher EM, Nienaber CA, Eagle KA. Aortic expansion after acute type B aortic dissection. Ann Thorac Surg 2012; In Press.

 

Abstracts Published or In Press

Das S, Isselbacher E, Hagan P, Evangelista A, Fattori R, Suzuki T, Oh JK, Sechtem U, Robles JM, Deutsch HJ, Gilon D, Karavite D, Russman P, Armstrong WF, Deeb GM, Bruckman D, Nienaber C, Eagle KA. Practice variations in utilization of diagnostic techniques to evaluate acute aortic dissection - results from the International Registry of Aortic Dissection (IRAD). J Am Coll Cardiol 1999; 33(2):310A.

Hagan PG, Nienaber CA, Das S, Evangelista A, Fattori R, Suzuki T, Oh JK, Sechtem U, Robles JM, Deutsch HJ, Gilon D, Bruckman D, Karavite D, Russman P, Mehta RJ, Pape L, Armstrong WF, Deeb GM, Isselbacher E, Eagle KA. Acute aortic dissection: Modern clinical spectrum - results from the International Registry for Aortic Dissection (IRAD). J Am Coll Cardiol 1999; 33(2):242A.

Nienaber CA, Fattori R, Bruckman D, Das S, Evangelista A, Suzuki T, Oh JK, Sechtem U, Robles JM, Deutsch HJ, Gilon D, Pape L, Karavite D, Russman P, Deeb GM, Isselbacher E, Eagle KA. Current management of Type A acute aortic dissection: results from the International Registry of Aortic Dissection. J Am Coll Cardiol 1999; 33(2):242A.

Moore AG, Oh JK, Bruckman D, Karavite D, Malouf J, Russman PL, Hagan P, Isselbacher E, Evangelista A, Pape L, Fattori R, Suzuki T, Sechtem U, Robles JM, Deutsch HJ, Gilon D, Das S, Deeb GM, Nienaber CA, Eagle KA. The utility of transesophageal echocardiography in the diagnosis and management of aortic dissection: an analysis of data from the International Registry of Aortic Dissection (IRAD). J Am Coll Cardiol 1999; 33(2):470A.

Evangelista A, Bruckman D, Gaca C, Hagan PG, Oh JK, Malouf J, Moore AG, Sechtem U, Llovet S, Deutsch HJ, Diedrichs H, Gilon D, Nienaber CA, O’Gara PT, Karavite DJ, Russman PL, Armstrong WF, Deeb GM, Suzuki T, Isselbacher E, Eagle KA, Pape L. Presentation, clinical findings and outcomes among patients with acute definitive intramural hematoma – results from the International Registry of Acute Aortic Dissection (IRAD). J Am Coll Cardiol 2000; 35:324A.

Fattori R, Napoli G, Bruckman D, Isselbacher E, Evangelista A, Oh JK, Malouf J, Sechtem U, Llovet A, Deutsch HJ, Diedrichs H, Gilon D, Pape L, O’Gara PT, Karavite DJ, Russman PL, Hagan PG, Armstrong WF, Deeb BM, Suzuki T, Eagle KA, Nienaber CA. Acute aortic dissection in women: Comparative analysis among genders – results from the International Registry of Acute Aortic Dissection (IRAD). J Am Coll Cardiol 2000; 35:284A.

Eagle KA, Bruckman D, Isselbacher E, Evangelista A, Fattori R, Oh JK, Moore AG, Malouf J, Sechtem U, Llovet A, Deutsch HJ, Gilon D, Pape L, O’Gara PT, Karavite D, Russman P, Hagan PG, Armstrong WF, Deeb GM, Nienaber CA, Suzuki T. Predictive of mortality in patients with type A acute aortic dissections – results from the International Registry of Acute Aortic Dissection (IRAD). J Am Coll Cardiol 2000; 35:323A.

Freeman RV, Bruckman D, Hagan P, Suzuki T, Isselbacher E, Evangelista A. Fattori R, Oh JK, Moore AG, Sechtem U, Llovet A, Deutsch HJ, Gilon D, Pape L, O’Gara PT, Karavite DJ, Russman PL, Armstrong WF, Deeb GM, Nienaber CA, Eagle KA. A non-linear model for mortality prediction in patients with Type A Acute Aortic Dissection. A study from the International Registry of Acute Aortic Dissection (IRAD). J Am Coll Cardiol 2000; 35:275A.

Januzzi JL, Sabatine MS, Evangelista A, Bruckman D, Fattori R, Oh JK, Moore AG, Malouf J, Sechtem U, Llovet A, Deutsch HJ, Gilon D. Iatrogenic aortic dissection—results from the International Registry of Aortic Dissection (IRAD). Circulation 2000; 102:.

Mehta RJ, O’Gara PT, Hagan PG, Bossone E, Llovet A, Cooper J, Bruckman D, Gilon D. Acute aortic dissection in the elderly: Clinical characteristics, management, and outcomes in the current era. J Am Coll Cardiol 2001; 37:145A.

Mehta RH, Hagan PG, Suzuki T, Bossone E, Gilon D, Llovet A, Cooper J, Pape L, Armstrong WF, Bruckman D, Nienaber CA, Eagle KA. Predicting in-hospital mortality in acute Type A aortic dissection: lessons from the International Registry of Aortic Dissection (IRAD). J Am Coll Cardiol 2001; 37:492A.

Fattori R, Eagle KA, Williams D, Cooper J, Isselbacher E, Nienaber C. Percutaneous therapeutic procedures in acute aortic dissection: evidence for benefit is mounting. J Am Coll Cardiol 2001; 37:514A.

Suzuki T, Nienaber CA, Hagan PG, Bossone E, Gilon D, Cooper JV, Bruckman D, Armstrong WF, Eagle KA, Mehta RH. Mortality in type B aortic dissections in the current era: Results from the International Registry of Aortic Dissection (IRAD). J Am Coll Cardiol 2001; 37:514A.

Evangelista A, Elorz C, Avegliano G, Cooper J, Nienaber C, Fattori R, Suzuki T, Sechtem U, Pape L, Eagle K. Management and one-month mortality in patients with acute aortic intramural haematoma. Results from the International Registry of Acute Aortic Dissection (IRAD). European Heart Journal 2001; 22:599.

Mehta RH, Hagan PG, Suzuki T, Bossone E, Gilon D, Llovet A, Cooper J, Armstrong WF, Nienaber CA, Eagle KA. Multivariable model to predict in-hospital mortality in acute type A aortic dissection. European Heart Journal 2001; 22:598.

Fattori R, Eagle KA, Williams D, Mehta RH, Maroto LC, Cooper J, Isselbacher E, Nienaber CA. Percutaneous therapeutic procedures in acute aortic dissection: lessons from International Registry of Acute Aortic Dissection. European Heart Journal 2001; 22:599.

Suzuki T, Nienaber CA, Hagan PG, Bossone E, Gilon D, Cooper J, Armstrong WF, Maroto LC, Eagle KA, Mehta RH. Predicting mortality in type B acute aortic dissections. European Heart Journal 2001; 22:323.

Bossone E, Rampoldi V, Trimarchi S, Hagan PG, Cooper J, Smith D, Suzuki T, Nienaber C, Eagle KA, Mehta RH. Pulse deficit: an independent predictor of in-hospital complications and mortality in patients with type A aortic dissection. Circulation 2001; 104:524-525.

Mehta RH, Manfredini R, Bossone E, Smith DE, Cooper JV, Llovet A, Suzuki T, Nienaber CA, Eagle KA. Does circadian rhythm influence the risk of acute aortic dissection? J Am Coll Cardiol 2002; 39:241A.

Nallamothu BK, Mehta RH, Saint S, Eagle KA. Syncope in aortic dissection: diagnostic, prognostic, and clinical implications. J Am Coll Cardiol 2002; 39:241A.

Richartz BM, Cooper JV, Smith DE, Mehta RH, Eagle KA, Nienaber CA. Excess mortality of type A aortic dissection in women: impact of delayed diagnosis. J Am Coll Cardiol 2002; 39:241A.

Richartz BM, Smith DE, Cooper JV, Mehta RM, Eagle KA, Nienaber CA. New classification of aortic dissection with improved impact on prognosis. J Am Coll Cardiol 2002; 39:264A.

Mehta RH, Manfredini R, Hassan F, Bossone E, Cooper JV, Nienaber C, Isselbacher EM, Eagle KA. Seasonal variation in the risk of acute aortic dissections. European Heart Journal 2002; 4:10.

Richartz, BM, Schiller F, Bossone E, Cooper JV, Evangelista A, Nienaber CA. Aortic arch dissection as a distinct entity: lessons learned from IRAD. Circulation 2002; 106:473.

Suzuki T, Mehta R, Sakomura Y, Sumiyoshi T, Bossone E, Trimarchi S, Cooper J, Smith D, Isselbacher E, Nienaber C. Clinical presentation, diagnosis, management and outcomes of acute type B aortic dissection in the current era – lessons from the international registry of aortic dissection (IRAD). Circulation 2002; 106:501.

Gilon D, Mehta RH, Oh JK, Januzzi JL, Bossone E, Cooper JV, Smith DE, Nienaber CA, Isselbacher EM. Clinical characteristics and in-hospital outcomes of patients with cardiac tamponade complicating acute type A aortic dissection. Circulation 2002; 106:672.

Al-Marayati F, Isselbacher EM, Mehta RH, O’Gara PT, Sechtem U, Bossone E, Evangelista A, Oh, JK, Nienaber CA, Eagle KA. Marfan syndrome: a distinct and highly lethal cause of aortic dissection; lessons from the international registry of aortic dissection. Circulation 2002; 106:473.

Beckman JA, Mehta RH, Bossone E, Cooper JV, Smith DE, Sechtem U, Pape L, O'Gara PT. Renal failure on presentation predicts morbidity and mortality in aortic dissection. J Am Coll Cardiol 2003; 41:235-236A.

Bossone E, Mehta RH, Trimarchi S, Cooper JV, Smith DE, Evangelista A, Myrmel T, Oh J, Nienaber CA, Eagle KA, Isselbacher EM. Coronary artery involvement in patients with acute type A aortic dissection: clinical characteristics and in-hospital outcomes. J Am Coll Cardiol 2003; 41:235A.

Januzzi JL, Isselbacher EM, Fattori R, Cooper JV, Smith DE, Eagle KA, Nienaber CA, Pape LA. Characterizing the young patient with aortic dissection: results from the International Registry of Aortic Dissection (IRAD). J Am Coll Cardiol 2003; 41:253A.

Eagle KA, Nienaber CA, Mehta RH, Cooper JV, Smith DE, Myrmel T, Sechtem U, Bossone E, Januzzi JL, Isselbacher EM. Trends in management and outcomes of acute aortic dissection: lessons learned from the first 1,000 patients enrolled in the International Registry of Acute Aortic Dissection (IRAD). J Am Coll Cardiol 2003; 41:529A.

Mehta RH, Manfredini R, Portaluppi F, Hutchison S, Cooper JV, Penn M, Bossone E, Evangelista A, Eagle KA, Nienaber CA. Influence of chronobiological variation in the risk of acute aortic dissection on in-hospital mortality. J Am Coll Cardiol 2003; 41:288A.

Trimarchi S, Nienaber CA, Rampoldi V, Mehta RH, Bossone E, Cooper JV, Smith DE, Oh JK, Isselbacher EM, Suzuki T, Eagle KA. Preoperative predictive risk model for mortality in patients with acute type A aortic dissection undergoing surgery: lessons from the International Registry of Acute Aortic Dissection (IRAD). J Am Coll Cardiol 2003; 41:512-513A.

Patel SJ, Mehta RH, Pape L, Hutchison S, Smith DE, Cooper JV, O’Gara PT, Suzuki T, Isselbacher EM, Nienaber CA, Eagle KA. Hospital volume and mortality in acute aortic dissection: does low volume predict worse outcome? J Am Coll Cardiol 2003; 41:304A.

Collins JS, Evangelista A, Nienaber CA, Bossone E, Cooper JV, Isselbacher EM, Penn M, Mehta RH. Differences in clinical features, management and outcomes of acute aortic dissection in patients with and without prior cardiac surgery. Circulation 2003; 108:480-481.

Bossone E, Isselbacher EM, Nienaber CA, Gilon D, Cooper JV, Evangelista A, Suzuki T, Mehta RH. Simple decision rule for risk stratification of elderly with acute type B aortic dissection. Circulation 2003; 108:481.

Trimarchi S, Fattori R, Nienaber CA, Cooper JV, Smith DE, Rampoldi V, Sangiorgi G, Myrmel T, Suzuki T, Oh JK, Isselbacher EM, Eagle KA. Preoperative hemodynamic status as predictor of surgical mortality in acute type A aortic dissection patients: insights from the International Registry of Acute Aortic Dissection (IRAD). J Am Coll Cardiol 2004; 43:461-462A.

Bossone E, Mehta RH, Gilon D, Hutchison S, Distante A, Llovet A, O'Gara P, Cooper JV, Fang J, Januzzi J, Nienaber CA, Eagle KA, Armstrong WF. Prognostic role of transesophageal echocardiography in acute type A aortic dissection. J Am Coll Cardiol 2004; 43:19A

Tsai TT, Isselbacher EM, Nienaber CA, Evangelista A, Fang J, Smith DE, Cooper JV, Hutchison S, Bossone E, O'Gara P, Eagle KA, Mehta RH. Shock in patients with acute aortic dissection: clinical characteristics, risk factors and outcomes. J Am Coll Cardiol 2004; 43:22A.

Suzuki T, Trimarchi S, Smith D, Nienaber C, Evangelista A, Sakomura Y, Sumiyoshi T, Cooper JV, Pape L, Rampoldi V, Sangiorgi G, Fattori R, Isselbacher E, Eagle K. Early diagnosis of acute aortic dissection – identification of clinical variables associated with early diagnosis and determination of the usefulness of biochemical diagnosis as shown by the International Registry of Acute Aortic Dissection (IRAD) database. Circulation 2004; 110:370.

Mehta RH, Manfredini R, Bossone E, Fattori R, Evangelista A, Cooper JV, Sechtem U, Isselbacher EM, Nienaber CA, Eagle KA. The winter peak in the risk of acute aortic dissection is independent of the varying climatic conditions at different geographical locations. Circulation 2004; 110:670.

Mukherjee D, Eagle KA, Evangelista A, Sechtem U, Suzuki T, Trimarchi S, Llovet A, Myrmel M,  O'Gara PT, Fang J, Cooper JV, Oh JK, Januzzi JL, Hutchison S, Fattori R, Pape LA, Isselbacher EM, Nienaber CA. Implications of periaortic hematoma in patients with acute aortic dissection: insights from the International Registry of Aortic Dissection. J Am Coll Cardiol 2005; 45:380A.

Pape LA, Januzzi J, Cooper JV, Fattori R, Evangelista A, Suzuki T, Trimarchi S, Bossone E, Oh J, Hutchison S, Beckman J, Nienaber CA, Isselbacher E, Eagle KA. Many type A aortic dissections occur at diameters less than generally perceived. Circulation 2005; 112:534.

Tsai TT, Evangelista A, Nienaber C, Sechtem U, Fattori R, Myrmel T, Llovet A, Cooper JV, Fang J, Isselbacher E, Eagle KA. Long-term survival in patients presenting with type A aortic dissection: insights from the International Registry of Acute Aortic Dissection (IRAD). Circulation 2005; 112:534-535.

Tsai TT, Fattori R, Trimarchi S, Nienaber C, Myrmel T, Hutchison S, Sechtem U, Cooper JV, Fang J, Pape L, Januzzi J, Eagle KA, Isselbacher E. Long-term survival in patients with type B acute aortic dissection: insights from the International Registry of Acute Aortic Dissection (IRAD). Circulation 2005; 112:535.

Trimarchi S, Nienaber CA, Rampoldi V, Myrmel T, Suzuki T, Tolva V, Deeb MG, Upchurch G, Cooper JV, Fang J, Isselbacher EM, Sundt T, Eagle KA. Role and results of surgery in acute type B dissection: insights from the International Registry of Aortic Dissection (IRAD). Circulation 2005; 112:712.

Raghupathy A, Nienaber C, Myrmel T, Fattori R, Sechtem U, Oh J, Cooper JV, Eagle K, Isselbacher E, Bossone E. Geographical variation in acute type A aortic dissection: insights from the International Registry of Aortic Dissection (IRAD). Circulation 2005; 112:712.

Tsai TT, Evangelista A, Nienaber CA, Myrmel T, Sechtem U, Cooper JV, Suzuki T, Fattori R, Distante A, Sundt T, Beckman J, Januzzi J, Isselbacher EM, Eagle KA. Partial false lumen thrombosis as a predictor of mortality in patients with type B acute aortic dissection: insights from the International Registry of Acute Aortic Dissection (IRAD). J Am Coll Cardiol 2006; 47:315A.

Rampoldi V, Trimarchi S, Eagle KA, Nienaber CA, Oh JK, Bossone E, Myrmel T, De Vincentiis C, Cooper JV, Fang J, Fattori R, Sechtem U, Isselbacher EM. Simple risk models to predict surgical mortality in acute aortic dissection: the IRAD score. J Am Coll Cardiol 2006; 47:274A.

Tsai TT, Eagle KA, Fattori R, Trimarchi S, Cooper JV, Isselbacher E, Nienaber C, Bossone E. Characterization of medically managed patients with acute type A aortic dissection: insights from the International Registry of acute Aortic Dissection (IRAD). European Heart Journal 2006.

Trimarchi S, Nienaber CA, Tsai T, Llovet A, Froehlich J, Rampoldi V, Grassi V, Pape L, Oh J, Cooper JV, Gilon D, Fattori R, Isselbacher EM, Eagle KA. In search for optimal treatment of complicated acute type B aortic dissections: insights from the International Registry of Aortic Dissection (IRAD). Circulation 2006;114:432.

Tsai T, Nienaber CA, Isselbacher EM, Trimarchi S, Bossone E, Evangelista A, Oh JK, O’Gara P, Suzuki T, Hutchison S, Cooper JV, Meinhardt G, Myrmel T, Eagle KA, Froehlich J. Acute type A aortic dissection: does a primary tear in the aortic arch affect management and outcomes? Insights from the International Registry of Acute Aortic Dissection (IRAD). Circulation 2006; 114:432.

Tsai T, Isselbacher EM, Trimarchi S, Bossone E, Pape L, Januzzi JL, Evangelista A, Oh JK, Llovet A, Beckman J, Cooper JV, Froehlich J, Fattori R, Eagle KA, Nienaber CA. Acute type B aortic dissection: does aortic arch involvement affect management and outcomes? Insights from the International Registry of Acute Aortic Dissection (IRAD). Circulation 2006;114:433.

Fattori R, Tsai TT, Myrmel T, Hutchison SJ, Trimarchi S, Kische S, Demertzis S, Cooper JV, Eagle KA, Pyeritz RE, Isselbacher EM, Nienaber CA. Emergency treatment of acute type B dissection: is surgery still justified? Results from the International Registry of Aortic Dissection (IRAD). J Am Coll Cardiol 2007; 49:374A.

Suzuki T, Distante A, Sabino F, Sizza A, Villani M, Trimarchi S, Salerno J, Fracella S, Ignone G, De Rinaldis G, Nowak R, Birkhahn R, Hollander J, Counselman F, Bossone E, Eagle KA. A biomarker for diagnosing acute aortic dissection: preliminary experience with the smooth muscle troponin-like protein, calponin.  J Am Coll Cardiol 2007; 49:374A.

Trimarchi S, Eagle KA, Nienaber CA, Suzuki T, O’Gara PT, Hutchison SJ, Rampoldi V, Bossone E, Evangelista A, Tsai TT, Froehlich JB, Cooper JV, Smith DE, Meinhardt GW, Sundt III TM, Myrmel T, Isselbacher EM. Importance of pain and hypertension in acute type B aortic dissection: insights from the International Registry of Acute Aortic Dissection (IRAD). J Am Coll Cardiol 2007; 49:284A.

Ramanath VJ, Nienaber CA, Evangelista A, Oh JK, Llovet A, Beckman JA, Hirsch AT, Harris KM, Cooper JV, Tsai TT, Eagle KA, Isselbacher EM, Froehlich JB.  Risk factors, management, and outcomes of recurrent acute aortic dissection in patients from the International Registry of Acute Aortic Dissection (IRAD).  AHA Quality of Care and Outcomes Research Conference 2007.