The International Registry of Acute Aortic Dissection (IRAD) is a consortium of research centers evaluating the current management and outcomes of acute aortic dissection and intramural hematoma. It was established in 1996, and is comprised of 58 large referral centers in 13 countries. IRAD endeavors to assess the etiological factors, modes of presentation, clinical features, treatment, and hospital and post-discharge outcomes of patients with acute aortic dissection around the world.

Projects focus on a range of topics, including timing of symptom onset, nuances of presentation and the impact on diagnosis, hemodynamic signs of aortic dissection, initial and chronic medical therapy, selection of diagnostic imaging, and best practices in surgical, endovascular, and medical management.

Furthermore, working groups to identify new breakthroughs in diagnosis and treatment have been developed, including groups targeting: the genetic basis of aortic dissection; surgical and endovascular approaches; and how patients should be followed and informed about the disease process. IRAD is poised to continue enrolling centers and patients in order to further our efforts to improve practice and gain knowledge regarding this devastating disease.

The work performed by this collaborative has elucidated new information on aortic disease and informed guidelines.  We are encouraged by the continued enthusiasm of patients and providers for this work, and are glad to have you here.  Please review the participating sites, investigators, and publications provided here, and contact the coordinating center with any questions.


MCORRP at the University of Michigan Medical Center (Michigan Medicine) is the Coordinating Center for IRAD.  Learn more about MCORRP.

This research is generously supported by: